Importin 9 antibody (AA 601-729) (Biotin)

Catalog No. ABIN902692

This Rabbit Polyclonal antibody specifically detects Importin 9 in WB, ELISA, IHC (p) and IHC (fro). It exhibits reactivity toward Mouse.

Quick Overview for Importin 9 antibody (AA 601-729) (Biotin) (ABIN902692)

Target: Importin 9 (IPO9)

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Importin 9 antibody is conjugated to Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-Importin 9 Antibody (Biotin)

Binding Specificity: AA 601-729

Cross-Reactivity: Mouse

Predicted Reactivity: Human,Rat,Dog,Cow,Sheep,Pig,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Importin 9

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for Importin 9

Target: Importin 9 (IPO9)

Alternative Name: Importin 9

Background:

Synonyms: B cell antigen receptor Ig beta associated protein 1, BPM 90, BPM L, BPM-L, BPM90, BPML, IBAP 1, Imp 9, Importin 9, Importin9, Importin-9, Novel centrosomal protein RanBPM, RAN binding protein 9, Ran binding protein centrosomal, Ran binding protein M, Ran BP9, Ran-binding protein 9, Ran-binding protein M, RANB9_HUMAN, RanBP 7, RANBP 9, RanBP7, RanBP9, RanBPM.

Background: May act as an adapter protein to couple membrane receptors to intracellular signaling pathways. May be involved in signaling of ITGB2/LFA-1 and other integrins. Enhances HGF-MET signaling by recruiting Sos and activating the Ras pathway. Involved in activation of androgen and glucocorticoid receptor in the presence of their cognate hormones. Stabilizes TP73 isoform Alpha, probably by inhibiting its ubiquitination, and increases its proapoptotic activity. Inhibits the kinase activity of DYRK1A and DYRK1B. Inhibits FMR1 binding to RNA.Tissue specificity: Ubiquitously expressed, with highest levels in testes, placenta, heart, and muscle, and lowest levels in lung. Within the brain, expressed predominantly by neurons in the gray matter of cortex, the granular layer of cerebellum and the Purkinje cells.

Gene ID: 10048

Pathways: Protein targeting to Nucleus