PLEKHG6 antibody (AA 451-550) (Cy3)

Catalog No. ABIN907482

The Cy3-conjugated Rabbit Polyclonal anti-PLEKHG6 antibody (ABIN907482) specifically detects PLEKHG6 in WB, IF (cc) and IF (p). The antibody is reactive with Human samples.

Quick Overview for PLEKHG6 antibody (AA 451-550) (Cy3) (ABIN907482)

Target: PLEKHG6 (Pleckstrin Homology Domain Containing, Family G (With RhoGef Domain) Member 6 (PLEKHG6))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PLEKHG6 antibody is conjugated to Cy3

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-PLEKHG6 Antibody (Cy3)

Binding Specificity: AA 451-550

Predicted Reactivity: Human,Mouse,Rat,Dog,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human MyoGEF

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for PLEKHG6

Target: PLEKHG6 (Pleckstrin Homology Domain Containing, Family G (With RhoGef Domain) Member 6 (PLEKHG6))

Alternative Name: MyoGEF

Background:

Synonyms: Myosin interacting guanine nucleotide exchange factor, PH domain containing family G member 6, Pleckstrin homology domain containing family G with RhoGef domain member 6, Pleckstrin homology domain-containing family G member 6, PLEKHG6_PKHG6_HUMAN

Background: MyoGEF functions as a guanine nucleotide exchange factor activating the small GTPase RHOA, which, in turn, induces myosin filament formation. It activates RHOG but not activate RAC1, or to a much lower extent than RHOA and RHOG. Part of a functional unit, involving MyoGEF, MYH10 and RHOA, at the cleavage furrow to advance furrow ingression during cytokinesis. In epithelial cells, required for the formation of microvilli and membrane ruffles on the apical pole. Along with EZR, required for normal macropinocytosis.

Gene ID: 55200