NOC2L antibody (AA 251-350) (HRP)

Catalog No. ABIN908595

The HRP-conjugated Rabbit Polyclonal anti-NOC2L antibody (ABIN908595) specifically detects NOC2L in IHC (fro) and IHC (p). The antibody is reactive with Human samples.

Quick Overview for NOC2L antibody (AA 251-350) (HRP) (ABIN908595)

Target: NOC2L (Nucleolar Complex Associated 2 Homolog (NOC2L))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NOC2L antibody is conjugated to HRP

Application: Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-NOC2L Antibody (HRP)

Binding Specificity: AA 251-350

Purpose: NOC2L Polyclonal Antibody, HRP Conjugated

Predicted Reactivity: Human,Mouse,Rat,Cow,Sheep,Pig

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human NOC2L

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for NOC2L

Target: NOC2L (Nucleolar Complex Associated 2 Homolog (NOC2L))

Alternative Name: NOC2L

Background:

Synonyms: NIR, NOC2 like, Novel INHAT inhibitor of histone acetyltransferase repressor, Nucleolar complex associated 2 homolog S. cerevisiae, Protein NOC2 homolog, NOC2L_HUMAN.

Background: NOC2L is a transcriptional corepressor with inhibitor of histone acetyltransferase (INHAT) activity. NOC2L or NIR (Novel INHAT Repressor) is ubiquitously expressed throughout embryonic development and adulthood. It is a potent transcriptional corepressor that is not blocked by histone deacetylase inhibitors and is capable of silencing both basal and activator-driven transcription. NOC2L directly binds to nucleosomes and core histones and prevents acetylation by histone acetyltransferases, thus acting as a bona fide INHAT.

Gene ID: 26155

Pathways: Negative Regulation of intrinsic apoptotic Signaling