RFFL antibody (AA 251-363) (FITC)

Catalog No. ABIN913500

This anti-RFFL antibody is a Rabbit Polyclonal antibody detecting RFFL in WB, IF (cc) and IF (p). Suitable for Human and Mouse.

Quick Overview for RFFL antibody (AA 251-363) (FITC) (ABIN913500)

Target: RFFL (Ring Finger and FYVE-Like Domain Containing 1 (RFFL))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RFFL antibody is conjugated to FITC

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-RFFL Antibody (FITC)

Binding Specificity: AA 251-363

Cross-Reactivity: Human, Mouse

Predicted Reactivity: Rat,Dog,Cow,Sheep,Pig,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human RING finger protein 189

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for RFFL

Target: RFFL (Ring Finger and FYVE-Like Domain Containing 1 (RFFL))

Alternative Name: RING finger protein 189

Background:

Synonyms: CARP-2, CARP2, Caspase regulator CARP2, Caspases 8 and 10 associated RING finger protein 2, Caspases-8 and -10-associated RING finger protein 2, E3 ubiquitin protein ligase rylin, E3 ubiquitin-protein ligase rylin, Fring, FYVE RING finger protein Sakura, FYVE-RING finger protein Sakura, Rffl, RFFL_HUMAN, Rylin, RING finger and FYVE like domain containing protein, RING finger and FYVE-like domain-containing protein 1, RING finger protein 189, RING finger protein 34 like, RING finger protein 34-like, RNF189, RNF34L.

Background: Has E3 ubiquitin protein ligase activity. Regulates the levels of CASP8 and CASP10 by targeting them for proteasomal degradation. Has anti-apoptotic activity. May bind phosphatidylinositol phosphates.

Gene ID: 117584