CEMIP antibody (AA 101-200) (Biotin)

Catalog No. ABIN917972

The Rabbit Polyclonal anti-CEMIP antibody is suitable to detect CEMIP in samples from Human, Mouse and Rat. It has been validated for WB, ELISA, IHC (fro) and IHC (p).

Quick Overview for CEMIP antibody (AA 101-200) (Biotin) (ABIN917972)

Target: CEMIP (Cell Migration Inducing Hyaluronan Binding Protein (CEMIP))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CEMIP antibody is conjugated to Biotin

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-CEMIP Antibody (Biotin)

Binding Specificity: AA 101-200

Cross-Reactivity: Human, Mouse, Rat

Predicted Reactivity: Dog,Cow,Horse,Chicken,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human TMEM2L

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for CEMIP

Target: CEMIP (Cell Migration Inducing Hyaluronan Binding Protein (CEMIP))

Alternative Name: CEMIP

Background:

Synonyms: CCSP1, TMEM2L, KIAA1199, Cell migration-inducing and hyaluronan-binding protein, CEMIP, HYBID

Background: Mediates depolymerization of hyaluronic acid (HA) via the cell membrane-associated clathrin-coated pit endocytic pathway. Binds to hyaluronic acid. Hydrolyzes high molecular weight hyaluronic acid to produce an intermediate-sized product, a process that may occur through rapid vesicle endocytosis and recycling without intracytoplasmic accumulation or digestion in lysosomes. Involved in hyaluronan catabolism in the dermis of the skin and arthritic synovium. Positively regulates epithelial-mesenchymal transition (EMT), and hence tumor cell growth, invasion and cancer dissemination. In collaboration with HSPA5/BIP, promotes cancer cell migration in a calcium and PKC-dependent manner. May be involved in hearing.

Gene ID: 57214

UniProt: Q8WUJ3