ACTN2 antibody (C-Term)

Catalog No. ABIN925860

This anti-ACTN2 antibody is a Rabbit Polyclonal antibody detecting ACTN2 in WB. Suitable for Human, Mouse, Rat, Cow, Dog, Zebrafish (Danio rerio), Chicken and Xenopus laevis.

Quick Overview for ACTN2 antibody (C-Term) (ABIN925860)

Target: ACTN2 (Actinin, alpha 2 (ACTN2))

Reactivity: Human, Mouse, Rat, Cow, Dog, Zebrafish (Danio rerio), Chicken, Xenopus laevis

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ACTN2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-ACTN2 Antibody

Binding Specificity: C-Term

Cross-Reactivity: Rat (Rattus), Human, Cow (Bovine), Dog (Canine), Chicken, Zebrafish (Brachydanio rerio), Frog

Immunogen: ACTN2 antibody was raised in rabbit using the C terminal of ACTN2 as the immunogen

Application Details

Application Notes: WB: 0.625 µg/mL
Optimal conditions should be determined by the investigator.

Comment:

ACTN2 Blocking Peptide, (ABIN939512), is also available for use as a blocking control in assays to test for specificity of this ACTN2 antibody

Restrictions: For Research Use only

Handling

Format: Lyophilized

Concentration: Lot specific

Buffer: Lyophilized powder. Add 100 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.

Handling Advice: Avoid repeated freeze/thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C, following reconstitution, aliquot and store at -20 °C.

Target Details for ACTN2

Target: ACTN2 (Actinin, alpha 2 (ACTN2))

Alternative Name: ACTN2

Background: The alpha-actinins are a multigene family of four actin-binding proteins related to dystrophin. The two skeletal muscle isoforms of alpha-actinin (ACTN2 and ACTN3) are major structural components of the Z-line involved in anchoring the actin-containing thin filaments. In humans, ACTN2 is expressed in all muscle fibres, while ACTN3 expression is restricted to a subset of type 2 fibres. Murine Actn2 and Actn3 are differentially expressed, spatially and temporally, during embryonic development and, in contrast to humans, alpha-actinin-2 expression does not completely overlap alpha-actinin-3 in postnatal skeletal muscle, suggesting independent function. Synonyms: Polyclonal ACTN2 antibody, Anti-ACTN2 antibody.

Pathways: Cell-Cell Junction Organization, Skeletal Muscle Fiber Development, Negative Regulation of Transporter Activity