WWOX antibody (C-Term)

Catalog No. ABIN926732

The Rabbit Polyclonal anti-WWOX antibody has been validated for WB. It is suitable to detect WWOX in samples from Human.

Quick Overview for WWOX antibody (C-Term) (ABIN926732)

Target: WWOX (WW Domain Containing Oxidoreductase (WWOX))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This WWOX antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-WWOX Antibody

Binding Specificity: C-Term

Purification: Purified

Immunogen: WWOX antibody was raised in rabbit using the C terminal of WWOX as the immunogen

Application Details

Application Notes: Optimal conditions should be determined by the investigator.

Comment:

WWOX Blocking Peptide, , is also available for use as a blocking control in assays to test for specificity of this WWOX antibody

Restrictions: For Research Use only

Handling

Format: Lyophilized

Concentration: Lot specific

Buffer: Lyophilized powder. Add 50 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.

Handling Advice: Avoid repeated freeze/thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C, following reconstitution, aliquot and store at -20 °C.

Target Details for WWOX

Target: WWOX (WW Domain Containing Oxidoreductase (WWOX))

Alternative Name: WWOX

Background: WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 2 WW domains and a short-chain dehydrogenase/reductase domain (SRD). The highest normal expression of this gene is detected in hormonally regulated tissues such as testis, ovary, and prostate. This expression pattern and the presence of an SRD domain suggest a role for this gene in steroid metabolism. The encoded protein is more than 90% identical to the mouse protein, which is an essential mediator of tumor necrosis factor-alpha-induced apoptosis, suggesting a similar, important role in apoptosis for the human protein. In addition, there is evidence that this gene behaves as a suppressor of tumor growth. Alternative splicing of this gene generates transcript variants that encode different isoforms. Synonyms: Polyclonal WWOX antibody, Anti-WWOX antibody, WW domain containing oxidoreductase antibody, D16S432E antibody, FOR antibody, FRA16D antibody, HHCMA56 antibody, PRO0128 antibody, SDR41C1 antibody, WOX1 antibody.