IGF1R antibody (Middle Region)

Catalog No. ABIN926846

The Rabbit Polyclonal anti-IGF1R antibody has been validated for WB and IHC. It is suitable to detect IGF1R in samples from Human, Mouse, Rat, Cow, Zebrafish (Danio rerio), Chicken, Pig and Xenopus laevis.

Quick Overview for IGF1R antibody (Middle Region) (ABIN926846)

Target: IGF1R (Insulin-Like Growth Factor 1 Receptor (IGF1R))

Reactivity: Human, Mouse, Rat, Cow, Zebrafish (Danio rerio), Chicken, Pig, Xenopus laevis

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IGF1R antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Product Details anti-IGF1R Antibody

Binding Specificity: Middle Region

Cross-Reactivity: Mouse (Murine), Rat (Rattus), Pig (Porcine), Cow (Bovine), Chicken, Zebrafish (Brachydanio rerio), Frog

Purification: Purified

Immunogen: IGF1 R antibody was raised in rabbit using the middle region of IGF1 as the immunogen

Application Details

Application Notes: WB: 0.2-1 µg/mL
Optimal conditions should be determined by the investigator.

Comment:

IGF1R Blocking Peptide, (ABIN937530), is also available for use as a blocking control in assays to test for specificity of this IGF1R antibody

Restrictions: For Research Use only

Handling

Format: Lyophilized

Concentration: Lot specific

Buffer: Lyophilized powder. Add 50 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.

Handling Advice: Avoid repeated freeze/thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C, following reconstitution, aliquot and store at -20 °C.

Target Details for IGF1R

Target: IGF1R (Insulin-Like Growth Factor 1 Receptor (IGF1R))

Alternative Name: IGF1R

Background: This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Synonyms: Polyclonal IGF1R antibody, Anti-IGF1R antibody, insulin-like growth factor 1 receptor antibody, CD221 antibody, IGFIR antibody, JTK13 antibody, MGC142170 antibody, MGC142172 antibody, MGC18216 antibody.

Pathways: RTK Signaling, Regulation of Hormone Metabolic Process, Regulation of Hormone Biosynthetic Process, Autophagy