FGD1 antibody (C-Term)

Catalog No. ABIN927334

This Rabbit Polyclonal antibody specifically detects FGD1 in WB. It exhibits reactivity toward Human, Cow, Dog, Rat and Mouse.

Quick Overview for FGD1 antibody (C-Term) (ABIN927334)

Target: FGD1 (FYVE, RhoGEF and PH Domain Containing 1 (FGD1))

Reactivity: Human, Cow, Dog, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FGD1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-FGD1 Antibody

Binding Specificity: C-Term

Cross-Reactivity: Mouse (Murine), Rat (Rattus), Cow (Bovine), Dog (Canine)

Purification: Purified

Immunogen: FGD1 antibody was raised in rabbit using the C terminal of FGD1 as the immunogen

Application Details

Application Notes: WB: 0.2-1 µg/mL
Optimal conditions should be determined by the investigator.

Comment:

FGD1 Blocking Peptide, (ABIN5613572), is also available for use as a blocking control in assays to test for specificity of this FGD1 antibody

Restrictions: For Research Use only

Handling

Format: Lyophilized

Concentration: Lot specific

Buffer: Lyophilized powder. Add 50 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.

Handling Advice: Avoid repeated freeze/thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C, following reconstitution, aliquot and store at -20 °C.

Target Details for FGD1

Target: FGD1 (FYVE, RhoGEF and PH Domain Containing 1 (FGD1))

Alternative Name: FGD1

Background: FGD1 contains Dbl (DH) and pleckstrin (PH) homology domains. It can bind specifically to the Rho family GTPase Cdc42Hs and stimulate the GDP-GTP exchange of the isoprenylated form of Cdc42Hs. It also stimulates the mitogen activated protein kinase cascade leading to c-Jun kinase SAPK/JNK1 activation. FGD1 has an essential role in embryonic development, and FGD1 gene mutations result in the human developmental disorder, Aarskog-Scott syndrome. Synonyms: Polyclonal FGD1 antibody, Anti-FGD1 antibody, FYVE, RhoGEF and PH domain containing 1, faciogenital dysplasia antibody.

Pathways: Neurotrophin Signaling Pathway