FGD1 antibody (N-Term)

Catalog No. ABIN927716

The Rabbit Polyclonal anti-FGD1 antibody has been validated for WB. It is suitable to detect FGD1 in samples from Human, Cow and Dog.

Quick Overview for FGD1 antibody (N-Term) (ABIN927716)

Target: FGD1 (FYVE, RhoGEF and PH Domain Containing 1 (FGD1))

Reactivity: Human, Cow, Dog

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FGD1 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-FGD1 Antibody

Binding Specificity: N-Term

Cross-Reactivity: Cow (Bovine), Dog (Canine)

Purification: Purified

Immunogen: FGD1 antibody was raised in rabbit using the N terminal of FGD1 as the immunogen

Application Details

Application Notes: WB: 0.2-1 µg/mL
Optimal conditions should be determined by the investigator.

Comment:

FGD1 Blocking Peptide, (ABIN939123), is also available for use as a blocking control in assays to test for specificity of this FGD1 antibody

Restrictions: For Research Use only

Handling

Format: Lyophilized

Concentration: Lot specific

Buffer: Lyophilized powder. Add 50 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.

Handling Advice: Avoid repeated freeze/thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C, following reconstitution, aliquot and store at -20 °C.

Target Details for FGD1

Target: FGD1 (FYVE, RhoGEF and PH Domain Containing 1 (FGD1))

Alternative Name: FGD1

Background: FGD1 contains Dbl (DH) and pleckstrin (PH) homology domains. It can bind specifically to the Rho family GTPase Cdc42Hs and stimulate the GDP-GTP exchange of the isoprenylated form of Cdc42Hs. It also stimulates the mitogen activated protein kinase cascade leading to c-Jun kinase SAPK/JNK1 activation. FGD1 has an essential role in embryonic development, and FGD1 gene mutations result in the human developmental disorder, Aarskog-Scott syndrome.FGD1 contains Dbl (DH) and pleckstrin (PH) homology domains. It can bind specifically to the Rho family GTPase Cdc42Hs and stimulate the GDP-GTP exchange of the isoprenylated form of Cdc42Hs. Synonyms: Polyclonal FGD1 antibody, Anti-FGD1 antibody, FYVE, RhoGEF and PH domain containing 1, faciogenital dysplasia antibody, AAS antibody, FGDY antibody, ZFYVE3 antibody.

Pathways: Neurotrophin Signaling Pathway