SIN3B antibody (Middle Region)

Catalog No. ABIN928396

This Rabbit Polyclonal antibody specifically detects SIN3B in WB. It exhibits reactivity toward Human, Mouse, Cow, Zebrafish (Danio rerio) and Xenopus laevis.

Quick Overview for SIN3B antibody (Middle Region) (ABIN928396)

Target: SIN3B (SIN3 Transcription Regulator Homolog B (SIN3B))

Reactivity: Human, Mouse, Cow, Zebrafish (Danio rerio), Xenopus laevis

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SIN3B antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-SIN3B Antibody

Binding Specificity: Middle Region

Cross-Reactivity: Mouse (Murine), Cow (Bovine), Frog, Zebrafish (Brachydanio rerio)

Purification: Purified

Immunogen: SIN3 B antibody was raised in rabbit using the middle region of SIN3 as the immunogen

Application Details

Application Notes: WB: 0.2-1 µg/mL
Optimal conditions should be determined by the investigator.

Comment:

SIN3B Blocking Peptide, (ABIN5616150), is also available for use as a blocking control in assays to test for specificity of this SIN3B antibody

Restrictions: For Research Use only

Handling

Format: Lyophilized

Concentration: Lot specific

Buffer: Lyophilized powder. Add 50 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.

Handling Advice: Avoid repeated freeze/thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C, following reconstitution, aliquot and store at -20 °C.

Target Details for SIN3B

Target: SIN3B (SIN3 Transcription Regulator Homolog B (SIN3B))

Alternative Name: SIN3B

Background: SIN3B acts as a transcriptional repressor. It interacts with MXI1 to repress MYC responsive genes and antagonize MYC oncogenic activities. Also, it interacts with MAD-MAX heterodimers by binding to MAD. The heterodimer then represses transcription by tethering SIN3B to DNA. The gene is also able to form a complex with FOXK1 which represses transcription. Synonyms: Polyclonal SIN3B antibody, Anti-SIN3B antibody, SIN3 homolog B, transcription regulator, yeast antibody, KIAA0700 antibody.