Glutaredoxin 2 antibody (Middle Region)

Catalog No. ABIN929001

Product Details anti-Glutaredoxin 2 Antibody

Target: Glutaredoxin 2 (GRX2)

Binding Specificity: Middle Region

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Glutaredoxin 2 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Purified

Immunogen: GLRX2 antibody was raised in rabbit using the middle region of GLRX2 as the immunogen

Application Details

Application Notes: WB: 0.2-1 µg/mL
Optimal conditions should be determined by the investigator.

Comment:

GLRX2 Blocking Peptide, catalog no. 33R-6922, is also available for use as a blocking control in assays to test for specificity of this GLRX2 antibody

Restrictions: For Research Use only

Handling

Format: Lyophilized

Concentration: Lot specific

Buffer: Lyophilized powder. Add 50 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.

Handling Advice: Avoid repeated freeze/thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C, following reconstitution, aliquot and store at -20 °C.

Target Details for Glutaredoxin 2

Target: Glutaredoxin 2 (GRX2)

Alternative Name: GLRX2 (GRX2 Products)

Synonyms: ECK1049 antibody, JW1051 antibody, CGI-133 antibody, GRX2 antibody, 1700010P22Rik antibody, AI645710 antibody, Grx2 antibody, glutaredoxin 2 (Grx2) antibody, glutaredoxin Grx2 antibody, thioredoxin antibody, glutaredoxin 2 antibody, glutaredoxin 2 (thioltransferase) antibody, grxB antibody, grx2 antibody, AF_RS10790 antibody, GLRX2 antibody, Glrx2 antibody

Background: GLRX2 is a glutathione-dependent oxidoreductase that facilitates the maintenance of mitochondrial redox homeostasis upon induction of apoptosis by oxidative stress.GLRX2 is involved in response to hydrogen peroxide and regulation of apoptosis caused by oxidative stress.GLRX2 acts as a very efficient catalyst of monothiol reactions because of its high affinity for protein glutathione-mixed disulfides.GLRX2 can receive electrons not only from glutathione (GSH), but also from thioredoxin reductase supporting both monothiol and dithiol reactions.GLRX2 efficiently catalyzes both glutathionylation and deglutathionylation of mitochondrial complex I, which in turn regulates the superoxide production by the complex. Synonyms: Polyclonal GLRX2 antibody, Anti-GLRX2 antibody, glutaredoxin 2 antibody, GRX2 antibody, bA101E13.1 antibody.

Pathways: Cell RedoxHomeostasis