MRGPRX2 antibody (Middle Region)

Catalog No. ABIN929387

Product Details anti-MRGPRX2 Antibody

Target: MRGPRX2 (G Protein-Coupled Receptor MRGX2 (MRGPRX2))

Binding Specificity: Middle Region

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MRGPRX2 antibody is un-conjugated

Application: Western Blotting (WB)

Purification: Purified

Immunogen: MRGPRX2 antibody was raised in rabbit using the middle region of MRGPRX2 as the immunogen

Application Details

Application Notes: WB: 0.2-1 µg/mL
Optimal conditions should be determined by the investigator.

Comment:

MRGPRX2 Blocking Peptide, catalog no. 33R-9456, is also available for use as a blocking control in assays to test for specificity of this MRGPRX2 antibody

Restrictions: For Research Use only

Handling

Format: Lyophilized

Concentration: Lot specific

Buffer: Lyophilized powder. Add 50 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.

Handling Advice: Avoid repeated freeze/thaw cycles.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C, following reconstitution, aliquot and store at -20 °C.

Target Details for MRGPRX2

Target: MRGPRX2 (G Protein-Coupled Receptor MRGX2 (MRGPRX2))

Alternative Name: MRGPRX2 (MRGPRX2 Products)

Synonyms: MRGX2 antibody, G370024M05Rik antibody, MrgB10 antibody, Mrgprb10 antibody, MrgB1 antibody, Mrgprb1 antibody, MAS related GPR family member X2 antibody, MAS-related GPR, member X2 antibody, MRGPRX2 antibody, Mrgprx2 antibody

Background: MRGPRX2 is an orphan receptor. It probably involved in the function of nociceptive neurons. It also may regulate nociceptor function and/or development, including the sensation or modulation of pain. Cortistatin-14 seems to be a high potency ligand at this receptor. Cortistatin has several biological functions including roles in sleep regulation locomotor activity, and cortical function. In receptor-expressing cells, cortistatin-stimulated increases in intracellular Ca2+ but had no effect on basal or forskolin-stimulated cAMP levels, suggesting that this receptor is G(q)-coupled. Synonyms: Polyclonal MRGPRX2 antibody, Anti-MRGPRX2 antibody, MAS-related GPR, member X2 antibody, MRGX2 antibody.