NR4A2 antibody

Catalog No. ABIN931119

The Mouse Monoclonal anti-NR4A2 antibody (Clone 447C2a) (ABIN931119) specifically detects NR4A2 in WB and DB. The antibody is reactive with Human samples.

Quick Overview for NR4A2 antibody (ABIN931119)

Target: NR4A2 (Nuclear Receptor Subfamily 4, Group A, Member 2 (NR4A2))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This NR4A2 antibody is un-conjugated

Application: Western Blotting (WB), Dot Blot (DB)

Clone: 447C2a

Product Details anti-NR4A2 Antibody

Cross-Reactivity: Human

Cross-Reactivity (Details): Other species not studied.

Purification: Protein G affinity chromatography

Immunogen: NR4 A2 antibody was raised in mouse using recombinant Human Nuclear Receptor Subfamily 4, Group A, Member 2

Isotype: IgG1

Application Details

Application Notes: WB: 0.2-2 µg/mL
Optimal conditions should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: Lot specific

Buffer: NR4 A2 antibody in PBS (3.0 mM KCl, 1.5 mM KH2 PO4 , 140 mM NaCl, 8.0 mM Na2 HPO4 (pH 7.4)) containing 1 % bovine serum albumin (BSA) and 0.05 % sodium azide (NaN3 ).

Preservative: Sodium azide

Precaution of Use: This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze/thaw cycles.
Dilute only prior to immediate use.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2-8 °C for up to one year. We recommend long term storage at -20 °C.

Target Details for NR4A2

Target: NR4A2 (Nuclear Receptor Subfamily 4, Group A, Member 2 (NR4A2))

Alternative Name: NR4A2

Background: This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson disease, schizophernia, and manic depression. Misregulation of this gene may be associated with rheumatoid arthritis. Four transcript variants encoding four distinct isoforms have been identified for this gene. Additional alternate splice variants may exist, but their full length nature has not been determined. Synonyms: Monoclonal NR4A2 antibody, Anti-NR4A2 antibody, Nuclear receptor subfamily 4 group A member 2 antibody, NOT antibody, RNR1 antibody, HZF-3 antibody, NURR1 antibody, TINUR antibody.

Pathways: Nuclear Receptor Transcription Pathway, Dopaminergic Neurogenesis, Steroid Hormone Mediated Signaling Pathway