ABL1 antibody (AA 577-650)

Catalog No. ABIN931298

The Mouse Monoclonal anti-ABL1 antibody is suitable to detect ABL1 in samples from Human. It has been validated for WB and ELISA.

Quick Overview for ABL1 antibody (AA 577-650) (ABIN931298)

Target: ABL1 (C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This ABL1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Clone: 7B11D6

Product Details anti-ABL1 Antibody

Binding Specificity: AA 577-650

Immunogen: ABL1 antibody was raised in Mouse using a purified recombinant fragment of ABL1(aa577-650) expressed in E. coli as the immunogen.

Isotype: IgG1

Application Details

Application Notes: ELISA: 1:10,000, WB: 1:500-1:2000
Optimal conditions should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Supplied as a liquid in ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze/thaw cycles.
Dilute only prior to immediate use.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term storage. Store at -20 °C for long term storage.

Target Details for ABL1

Target: ABL1 (C-Abl Oncogene 1, Non-Receptor tyrosine Kinase (ABL1))

Alternative Name: ABL1

Background: The ABL1 proto-oncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of ABL1 protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9,22) translocation results in the head-to-tail fusion of the BCR and ABL1 genes, leading to a fusion gene present in many cases of chronic myelogenous leukemia. Synonyms: Monoclonal ABL1 antibody, Anti-ABL1 antibody, V-abl Abelson murine leukemia viral oncogene homolog 1 antibody.

Pathways: Apoptosis, Regulation of Muscle Cell Differentiation, Platelet-derived growth Factor Receptor Signaling, Lipid Metabolism