MLL/KMT2A antibody (AA 3751-3968)

Catalog No. ABIN931441

This Mouse Monoclonal antibody specifically detects MLL/KMT2A in WB, IHC and ELISA. It exhibits reactivity toward Human.

Quick Overview for MLL/KMT2A antibody (AA 3751-3968) (ABIN931441)

Target: MLL/KMT2A (MLL) (Myeloid/lymphoid Or Mixed-Lineage Leukemia (MLL))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This MLL/KMT2A antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Clone: 10F8D7

Product Details anti-MLL/KMT2A Antibody

Binding Specificity: AA 3751-3968

Immunogen: MLL antibody was raised in Mouse using a purified recombinant fragment of MLL(aa3751-3968) expressed in E. coli as the immunogen.

Isotype: IgG1

Application Details

Application Notes: ELISA: 1:10,000, IHC: 1:200-1:1000, WB: 1:500-1:2000
Optimal conditions should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Supplied as a liquid in ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze/thaw cycles.
Dilute only prior to immediate use.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term storage. Store at -20 °C for long term storage.

Target Details for MLL/KMT2A

Target: MLL/KMT2A (MLL) (Myeloid/lymphoid Or Mixed-Lineage Leukemia (MLL))

Alternative Name: MLL

Background: MLL contains multiple conserved functional domains. One of these domains, the SET domain, is responsible for its histone H3 lysine 4 (H3K4) methyltransferase activity which mediates chromatin modifications associated with epigenetic transcriptional activation. This protein is processed by the enzyme Taspase 1 into two fragments, MLL-C and MLL-N. These fragments reassociate and further assemble into different multiprotein complexes that regulate the transcription of specific target genes, including many of the HOX genes. Synonyms: Monoclonal MLL antibody, Anti-MLL antibody, Myeloid/lymphoid leukemia antibody, ALL-1 antibody, ALL 1 antibody, HRX antibody, Lysine N-methyltransferase 2A antibody, Trithorax-like protein antibody, Zinc finger protein HRX antibody.

Pathways: Warburg Effect