Aurora Kinase B antibody

Catalog No. ABIN931443

The Mouse Monoclonal anti-Aurora Kinase B antibody (Clone 13E8D3) (ABIN931443) specifically detects Aurora Kinase B in WB and ELISA. The antibody is reactive with Human samples.

Quick Overview for Aurora Kinase B antibody (ABIN931443)

Target: Aurora Kinase B (AURKB)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Aurora Kinase B antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Clone: 13E8D3

Product Details anti-Aurora Kinase B Antibody

Immunogen: AURKB antibody was raised in Mouse using a purified recombinant fragment of AURKB expressed in E. coli as the immunogen.

Isotype: IgG1

Application Details

Application Notes: ELISA: 1:10,000, WB: 1:500-1:2000
Optimal conditions should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Supplied as a liquid in ascitic fluid containing 0.03 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze/thaw cycles.
Dilute only prior to immediate use.

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C for short term storage. Store at -20 °C for long term storage.

Target Details for Aurora Kinase B

Target: Aurora Kinase B (AURKB)

Alternative Name: AURKB

Background: The aurora family (A, B and C) are serine threonine kinases and key regulators of chromosome segregation during mitosis. Aurora kinase B is a chromosomal passenger protein that regulates chromosome segregation and cytokinesis. Aurora kinase B is associated with the level of genetic instability within tumours and patient survival. It is strongly expressed in exponentially proliferating bronchial epithelial cells in culture and that this expression is markedly reduced in confluent cells. It is also shown that almost all tumours show higher levels of Aurora kinase B expression than their matched normal lung tissues, which could therefore simply be a consequence of a higher proliferative index, or be typical of the progenitor cell and atypical of the bulk of normal lung cells. Synonyms: Monoclonal AURKB antibody, Anti-AURKB antibody, Serine/threonine-protein kinase 12 antibody, Aurora-B antibody, AIK2 antibody, AIM1 antibody, ARK2 antibody, AurB antibody, aurkb-sv1 antibody, aurkb-sv2 antibody, IPL1 antibody, STK12 antibody, aurkb antibody, AIM1 antibody, AURKB antibody, Aurora 1 antibody, STK1 antibody, STK5 antibody, Aurora and Ipl1 like midbody associated protein 1 antibody, Aurora kinase B antibody, Aurora related kinase 2 antibody, Aurora/IPL1 related kinase 2 antibody, Serine/theronine kinase 12 antibody, Serine/threonine protein kinase 12 antibody.

Pathways: TCR Signaling, Cell Division Cycle, Maintenance of Protein Location, Hepatitis C, Toll-Like Receptors Cascades