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Ret Proto-Oncogene antibody (AA 896-1063)

RET Reactivity: Human WB, ELISA Host: Mouse Monoclonal 6E4C4 unconjugated
Catalog No. ABIN931459
  • Target See all Ret Proto-Oncogene (RET) Antibodies
    Ret Proto-Oncogene (RET)
    Binding Specificity
    • 27
    • 21
    • 21
    • 16
    • 15
    • 15
    • 15
    • 14
    • 9
    • 8
    • 8
    • 8
    • 7
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    • 6
    • 5
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 896-1063
    Reactivity
    • 183
    • 100
    • 81
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Host
    • 206
    • 22
    • 2
    • 1
    • 1
    • 1
    Mouse
    Clonality
    • 201
    • 32
    Monoclonal
    Conjugate
    • 90
    • 18
    • 14
    • 13
    • 10
    • 9
    • 9
    • 9
    • 9
    • 9
    • 9
    • 8
    • 5
    • 5
    • 5
    • 5
    • 5
    • 1
    This Ret Proto-Oncogene antibody is un-conjugated
    Application
    • 191
    • 102
    • 66
    • 65
    • 58
    • 28
    • 22
    • 16
    • 15
    • 10
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA
    Immunogen
    Ret antibody was raised in Mouse using a purified recombinant fragment of Ret (aa896-1063) expressed in E. coli as the immunogen.
    Clone
    6E4C4
    Isotype
    IgG1
    Top Product
    Discover our top product RET Primary Antibody
  • Application Notes
    ELISA: 1:10,000, WB: 1:500-1:2000
    Optimal conditions should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    Supplied as a liquid in ascitic fluid containing 0.03 % sodium azide.
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Handling Advice
    Avoid repeated freeze/thaw cycles.
    Dilute only prior to immediate use.
    Storage
    4 °C/-20 °C
    Storage Comment
    Store at 4 °C for short term storage. Store at -20 °C for long term storage.
  • Target
    Ret Proto-Oncogene (RET)
    Alternative Name
    Ret (RET Products)
    Synonyms
    c-ret antibody, cret antibody, etID315074.13 antibody, ret1 antibody, wu:fd13h01 antibody, X-ret antibody, ret-A antibody, xret antibody, RET antibody, MTC1 antibody, CDHF12 antibody, CDHR16 antibody, HSCR1 antibody, MEN2A antibody, MEN2B antibody, PTC antibody, RET-ELE1 antibody, RET51 antibody, RET9 antibody, c-Ret antibody, ret proto-oncogene receptor tyrosine kinase antibody, ret proto-oncogene S homeolog antibody, ret proto-oncogene antibody, ret antibody, ret.S antibody, RET antibody, Ret antibody
    Background
    Ret is a receptor tyrosine kinase that functions as a multicompetent receptor complex in conjunction with other membrane-bound ligand-binding GDNF family receptors. Ligands that bind the Ret receptor include the glial cell line-derived neurotropic factor (GDNF) and its congeners neurturin, persephin and artemin. Alterations in the corresponding Ret gene are associated with diseases including papillary thyroid carcinoma, multiple endocrine neoplasia (type 2A and 2B), familial medullary thyroid carcinoma and a congenital developmental disorder known as Hirschsprung’s disease. The Tyr905 residue located in the Ret kinase domain plays a crucial role in Ret catalytic and biological activity. Substitution of Phe for Tyr905 dramatically inhibits Ret autophosphorylation activity. Synonyms: Monoclonal Ret antibody, Anti-Ret antibody, c-Ret antibody, Ret proto-oncogene antibody.
    Pathways
    RTK Signaling, Dopaminergic Neurogenesis, Regulation of Cell Size, Tube Formation
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