RORC antibody

Catalog No. ABIN932197

This Mouse Monoclonal antibody specifically detects RORC in DB. It exhibits reactivity toward Human.

Quick Overview for RORC antibody (ABIN932197)

Target: RORC (RAR-Related Orphan Receptor C (RORC))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This RORC antibody is un-conjugated

Application: Dot Blot (DB)

Clone: 162C2a

Product Details anti-RORC Antibody

Cross-Reactivity: Human

Cross-Reactivity (Details): Other species not studied.

Purification: Protein G affinity chromatography

Immunogen: RORC antibody was raised in mouse using recombinant Human Rar-Related Orphan Receptor C

Isotype: IgG2a

Application Details

Application Notes: Optimal conditions should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: Lot specific

Buffer: RORC antibody in PBS (3.0 mM KCl, 1.5 mM KH2 PO4 , 140 mM NaCl, 8.0 mM Na2 HPO4 (pH 7.4)) containing 1 % bovine serum albumin (BSA) and 0.05 % sodium azide (NaN3 ).

Preservative: Sodium azide

Precaution of Use: This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze/thaw cycles.
Dilute only prior to immediate use.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2-8 °C for up to one year. We recommend long term storage at -20 °C.

Target Details for RORC

Target: RORC (RAR-Related Orphan Receptor C (RORC))

Alternative Name: RORC

Background: The protein encoded by this gene is a DNA-binding transcription factor and is a member of the NR1 subfamily of nuclear hormone receptors. The specific functions of this protein are not known, however, studies of a similar gene in mice have shown that this gene may be essential for lymphoid organogenesis and may play an important regulatory role in thymopoiesis. In addition, studies in mice suggest that the protein encoded by this gene may inhibit the expression of Fas ligand and IL2. Two transcript variants encoding different isoforms have been found for this gene. Synonyms: Monoclonal RORC antibody, Anti-RORC antibody, RAR-related orphan receptor C antibody, TOR antibody, RORG antibody, RZRG antibody, NR1F3 antibody, MGC129539 antibody.

Pathways: Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway