CBP antibody

Catalog No. ABIN932995

This Mouse Monoclonal antibody specifically detects CBP in WB, IP, ICC and DB. It exhibits reactivity toward Human.

Quick Overview for CBP antibody (ABIN932995)

Target: CBP (CREBBP) (CREB Binding Protein (CREBBP))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CBP antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunocytochemistry (ICC), Dot Blot (DB)

Clone: CBP5I001

Product Details anti-CBP Antibody

Cross-Reactivity: Human, Mouse (Murine)

Cross-Reactivity (Details): Other species not studied.

Purification: Protein G affinity chromatography

Immunogen: CBP antibody was raised in mouse using recombinant Creb-Binding Protein (Cbp)

Isotype: IgG1

Application Details

Application Notes: WB: 0.2-2 µg/mL IP: 100-500 µg/sample, ICC: 2-100 µg/mL
Optimal conditions should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: Lot specific

Buffer: CBP antibody in PBS (3.0 mM KCl, 1.5 mM KH2 PO4 , 140 mM NaCl, 8.0 mM Na2 HPO4 (pH 7.4)) containing 1 % bovine serum albumin (BSA) and 0.05 % sodium azide (NaN3).

Preservative: Sodium azide

Precaution of Use: This product contains Sodium Azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze/thaw cycles.
Dilute only prior to immediate use.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2-8 °C for up to one year. We recommend long term storage at -20 °C.

Target Details for CBP

Target: CBP (CREBBP) (CREB Binding Protein (CREBBP))

Alternative Name: CBP

Background: Acetyltransferase enzyme. Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 coactivator. Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. CREBBP, as coactivator, augments the activity of phosphorylated CREB to activate transcription of cAMP-responsive genes. Synonyms: Monoclonal CBP antibody, Anti-CBP antibody, CREB binding protein antibody.

Pathways: TCR Signaling, Interferon-gamma Pathway, Stem Cell Maintenance, Chromatin Binding, Regulation of Lipid Metabolism by PPARalpha