hTSH antibody

Catalog No. ABIN94482

This anti- antibody is a Mouse Monoclonal antibody detecting in ELISA and RIA. Suitable for Human. This Primary Antibody has been cited in 1 publication.

Quick Overview for hTSH antibody (ABIN94482)

Target: hTSH

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: Un-conjugated

Application: ELISA, Radioimmunoassay (RIA)

Clone: TSH-116

Product Details

Purpose: Anti-hTSH Purified

Specificity: The antibody TSH-116 reacts with human thyroid stimulating hormone (hTSH, thyrotropin), a glycoprotein hormone produced by the anterior pituitary gland cells in response to signals from the hypothalamus gland in the brain. The TSH-116 reacts with association constant 1.1 x 10¹¹ l/mol. Following cross-reactivity expressed as binding of labelled hormone (% of total) was determined by solid phase RIA with excess of the antibody TSH-116: hTSH (78.9), hCG (20.3), hLH (23.2), hFSH (29.9).

Cross-Reactivity (Details): Human

Purification: Purified by protein-A affinity chromatography.

Purity: > 95 % (by SDS-PAGE)

Immunogen: Human thyrotropin.

Isotype: IgG2a

Application Details

Application Notes: RIA: The antibody TSH-116 is suitable in combination with the antibody TSH-51 for immunometric assays in the screening of neonatal hypothyroidism.

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Do not freeze.

Storage: 4 °C

Storage Comment: Store at 2-8°C. Do not freeze.

References

Jirkalová, Cáp, Straková, Príbysová, Plicka, Lomský: "Immunoradiometric and luminescence immunoenzymometric assay of human thyrotropin from dried blood spots for screening of neonatal hypothyroidism." in: European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies, Vol. 34, Issue 10, pp. 823-7, (1997) (PubMed).

Target Details

Target: hTSH

Background: Thyrotropin (hTSH) promotes the growth of the thyroid gland in the neck and stimulates it to produce more thyroid hormones. hTSH is composed of two subunits - alpha nad beta.,Thyrotropin