Actl7b antibody (N-Term)

Catalog No. ABIN950264

The Rabbit Polyclonal anti-Actl7b antibody is suitable to detect Actl7b in samples from Human. It has been validated for WB and EIA.

Quick Overview for Actl7b antibody (N-Term) (ABIN950264)

Target: Actl7b (Actin-Like 7b (Actl7b))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Actl7b antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Product Details anti-Actl7b Antibody

Binding Specificity: AA 68-97, N-Term

Specificity: This antibody reacts to ACTL7B.

Cross-Reactivity (Details): Species reactivity (tested):Human.

Purification: Affinity chromatography on Protein A

Immunogen: KLH conjugated synthetic peptide between 68-97 amino acids from the N-terminal region of human ACTL7B

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS containing 0.09 % (W/V) sodium azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for Actl7b

Target: Actl7b (Actin-Like 7b (Actl7b))

Alternative Name: ACTL7B

Background: The protein encoded by this gene is a member of a family of actin-related proteins (ARPs) which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene (ACTL7B), and related gene, ACTL7A, are intronless, and are located approximately 4 kb apart in a head-to-head orientation within the familial dysautonomia candidate region on 9q31. Based on mutational analysis of the ACTL7B gene in patients with this disorder, it was concluded that it is unlikely to be involved in the pathogenesis of dysautonomia. Unlike ACTL7A, the ACTL7B gene is expressed predominantly in the testis, however, its exact function is not known.Synonyms: Actin-like protein 7B, Actin-like-7-beta

Gene ID: 10880

NCBI Accession: NP_006677