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AIRE antibody (Middle Region)
AIRE
Reactivity: Human, Mouse
WB, IF, EIA
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-AIRE Antibody
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Target
See all AIRE Antibodies
AIRE
(Autoimmune Regulator (AIRE))
Binding Specificity
All epitopes for AIRE antibodies
AA 64-92, Middle Region
Reactivity
All reactivities for AIRE antibodies
Human, Mouse
Host
All hosts for AIRE antibodies
Rabbit
Clonality
All clonalities for AIRE antibodies
Polyclonal
Conjugate
All conjugates for AIRE antibodies
This AIRE antibody is un-conjugated
Application
All applications for AIRE antibodies
Western Blotting (WB), Immunofluorescence (IF), Enzyme Immunoassay (EIA)
Specificity
This antibody reacts to AIRE.
Cross-Reactivity (Details)
Species reactivity (tested):Human and Mouse.
Purification
Affinity chromatography on Protein A
Immunogen
KLH conjugated synthetic peptide between 64-92 amino acids from the Central region of human AIRE
Isotype
Ig Fraction
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Discover our top product AIRE Primary Antibody
Alternatives
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Format
Liquid
Concentration
0.25 mg/mL
Buffer
PBS containing 0.09 % (W/V) sodium azide as preservative
Preservative
Sodium azide
Precaution of Use
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Avoid repeated freezing and thawing.
Storage
4 °C/-20 °C
Storage Comment
Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Target Details for AIRE
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Target
AIRE
(Autoimmune Regulator (AIRE))
Alternative Name
AIRE / APECED (AIRE Products )
Synonyms
AIRE1 antibody, APECED antibody, APS1 antibody, APSI antibody, PGA1 antibody, autoimmune regulator antibody, autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy) antibody, AaeL_AAEL013794 antibody, CpipJ_CPIJ001208 antibody, CpipJ_CPIJ001209 antibody, AIRE antibody, Aire antibody
Background
This gene encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CBP. At least three splice variant mRNAs products have been described including one which results in a premature stop codon and a transcript predicted to be a candidate for nuclear-mediated decay (NMD). Defects in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED).Synonyms: Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein, Autoimmune regulator
Gene ID
326
NCBI Accession
NP_000374
Pathways
Chromatin Binding
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