ALOXE3 antibody (Middle Region)

Catalog No. ABIN950356

This Rabbit Polyclonal antibody specifically detects ALOXE3 in WB and EIA. It exhibits reactivity toward Human and Mouse.

Quick Overview for ALOXE3 antibody (Middle Region) (ABIN950356)

Target: ALOXE3 (Arachidonate Lipoxygenase 3 (ALOXE3))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ALOXE3 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Product Details anti-ALOXE3 Antibody

Binding Specificity: AA 230-260, Middle Region

Specificity: This antibody reacts to ALOXE3.

Cross-Reactivity (Details): Species reactivity (tested):Human and Mouse.

Purification: Affinity chromatography on Protein A

Immunogen: KLH conjugated synthetic peptide between 230-260 amino acids from the Central region of human ALOXE3

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS containing 0.09 % (W/V) sodium azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for ALOXE3

Target: ALOXE3 (Arachidonate Lipoxygenase 3 (ALOXE3))

Alternative Name: ALOXE3

Background: ALOXE3 is a member of the lipoxygenase family, which are catabolized by arachidonic acid-derived compounds. The encoded enzyme is a hydroperoxide isomerase that synthesizes a unique type of epoxy alcohol (8R-hydroxy-11R,12R-epoxyeicosa-5Z,9E,14Z-trienoic acid) from 12R-hydroperoxyeicosatetraenoic acid (12R-HPETE). This epoxy alcohol can activate the the nuclear receptor peroxisome proliferator-activated receptor alpha (PPARalpha), which is implicated in epidermal differentiation. Loss of function of the enzyme encoded by this gene results in ichthyosis, implicating the function of this gene in the differentiation of human skin.Synonyms: Epidermis-type lipoxygenase 3, e-LOX-3, eLOX3

Gene ID: 59344

NCBI Accession: NP_001159432

Pathways: Cell-Cell Junction Organization