Amyloid Fibrils antibody

Catalog No. ABIN950406

This anti- antibody is a Rabbit Polyclonal antibody detecting in WB, DB, IP, EIA, IHC (fro) and IF. Suitable for Human. This Primary Antibody has been cited in 3+ publications.

Quick Overview for Amyloid Fibrils antibody (ABIN950406)

Target: Amyloid Fibrils

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: Western Blotting (WB), Dot Blot (DB), Immunoprecipitation (IP), Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF)

Product Details

Cross-Reactivity (Details): Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human.

Purification: Protein A Chromatography

Immunogen: Fibrils prepared from Human Abeta42 peptide.

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.5 mg/mL

Buffer: PBS, 0.09 % Sodium Azide, 50 % Glycerol

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

References

Nakajima, Nishitsuji, Kawashima, Kuwabara, Mikawa, Uchimura, Akaji, Kashiwada, Kobayashi, Saito, Sakashita: "The polyphenol (-)-epigallocatechin-3-gallate prevents apoA-IIowa amyloidosis in vitro and protects human embryonic kidney 293 cells against amyloid cytotoxicity." in: Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis, Vol. 23, Issue 1, pp. 17-25, (2016) (PubMed).

Jackson, Onos, Pepper, Graham, Akeson, Byers, Reinholdt, Frankel, Howell: "DBA/2J genetic background exacerbates spontaneous lethal seizures but lessens amyloid deposition in a mouse model of Alzheimer's disease." in: PLoS ONE, Vol. 10, Issue 5, pp. e0125897, (2016) (PubMed).

Tang, Dai, He, Doty, Shultz, Sampson, Dai: "MEK guards proteome stability and inhibits tumor-suppressive amyloidogenesis via HSF1." in: Cell, Vol. 160, Issue 4, pp. 729-44, (2015) (PubMed).

Target Details

Target: Amyloid Fibrils

Background: Amyloid monomeric proteins can sometimes oligomerize into destructive amyloid fibrils. Amyloidogenic conformations of non-disease related proteins can be created by partial protein misfolding or denaturation. Many degenerative diseases are known to be related to the accumulation of misfolded proteins as amyloid fibres (1, 2). These include the amyloid-β peptide plaques and tau neurofibrillary tangles in senile plaques of Alzheimer's symptomology, the deposition of α-synuclein in the Lewy bodies of Parkinson's disease, and accumulation of polyglutamine-containing aggregates in Huntington's disease (2, 3).Synonyms: Fibrils, OC