Cathepsin K antibody (Middle Region)

Catalog No. ABIN951065

The Rabbit Polyclonal anti-Cathepsin K antibody is suitable to detect Cathepsin K in samples from Human. It has been validated for WB, IHC (p) and EIA.

Quick Overview for Cathepsin K antibody (Middle Region) (ABIN951065)

Target: Cathepsin K (CTSK)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Cathepsin K antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Product Details anti-Cathepsin K Antibody

Binding Specificity: AA 96-126, Middle Region

Specificity: This antibody recognizes Human Cathepsin K.

Cross-Reactivity (Details): Species reactivity (expected):Bovine, MonkeySpecies reactivity (tested):Human

Purification: Saturated Ammonium Sulfate (SAS) Precipitation

Immunogen: KLH conjugated synthetic peptide between 96-126 amino acids from the Central region of Human Cathepsin K Genename: CTSK

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS, 0.09 % (W/V) Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for Cathepsin K

Target: Cathepsin K (CTSK)

Alternative Name: Cathepsin K

Background: The protein encoded by this gene is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature. This gene may be subject to RNA editing. [provided by RefSeq].Synonyms: CTSK, CTSO, CTSO2, Cathepsin O, Cathepsin O2, Cathepsin X

Molecular Weight: 36966 Da

Gene ID: 1513

NCBI Accession: NP_000387

Pathways: Activation of Innate immune Response, Toll-Like Receptors Cascades