CD27 antibody (PE)

Catalog No. ABIN951257

The Hamster Monoclonal anti-CD27 antibody has been validated for FACS, IHC (fro) and Func. It is suitable to detect CD27 in samples from Mouse.

Quick Overview for CD27 antibody (PE) (ABIN951257)

Target: CD27 (CD27 Molecule (CD27))

Reactivity: Mouse

Host: Hamster

Clonality: Monoclonal

Conjugate: This CD27 antibody is conjugated to PE

Application: Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro)), Functional Studies (Func)

Clone: LG-3A10

Product Details anti-CD27 Antibody (PE)

Specificity: This Monoclonal Antibody is specific for the Mouse CD27 receptor.

Immunogen: MCD27 tag expressing clones AR0524 and AR0530 Donor: Armenian hamster spleen Fusion Partner: SP2/0 Murine Myeloma Partner

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0,1 mg/mL

Buffer: PBS, 0.02 % Sodium Azide, EIA grade BSA as a stabilizing protein to bring total protein concentration to 4-5 mg/mL

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: DO NOT FREEZE!

Storage: 4 °C

Storage Comment: Store the antibody undiluted at 2-8 °C.

Target Details for CD27

Target: CD27 (CD27 Molecule (CD27))

Alternative Name: CD27

Background: CD27 is part of the Tumor Necrosis Factor (TNF) family of receptors and is lymphocyte specific. Murine CD27 is expressed on the great majority of both αβ and γδ T lymphocytes, on a small population of peripheral B cells and on a very small subset of B220+ cells in the bone marrow. Murine CD27 is found on all thymocytes except a subset of CD4-CD8-precursors. There are two known basic functions of CD27 signaling. First, the binding of CD27 to CD70, a protein which is also expressed in T and B cells, provides costimulatory signals in lymphocyte proliferation and immunoglobulin production. Second, the association of CD27 with intracellular Siva, a proapoptotic protein, results in the induction of apoptotic events.Synonyms: CD27L receptor, T-cell activation antigen CD27, T14, TNFRSF7, Tumor necrosis factor receptor superfamily member 7

Gene ID: 21940

NCBI Accession: NP_001028298

UniProt: P41272

Pathways: Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints