Claudin 6 antibody (Middle Region)

Catalog No. ABIN951551

The Rabbit Polyclonal anti-Claudin 6 antibody has been validated for WB and EIA. It is suitable to detect Claudin 6 in samples from Human and Mouse.

Quick Overview for Claudin 6 antibody (Middle Region) (ABIN951551)

Target: Claudin 6 (CLDN6)

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Claudin 6 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Product Details anti-Claudin 6 Antibody

Binding Specificity: AA 133-163, Middle Region

Specificity: This antibody recognizes Human CLDN6. Other species not tested.

Purification: Protein A column, followed by peptide affinity purification

Immunogen: KLH conjugated synthetic peptide between 133-163 amino acids from the Central region of human CLDN6

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS, 0.09 % (W/V) Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for Claudin 6

Target: Claudin 6 (CLDN6)

Alternative Name: Claudin-6 / CLDN6

Background: Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. This gene encodes a component of tight junction strands, which is a member of the claudin family. The protein is an integral membrane protein and is one of the entry cofactors for hepatitis C virus. The gene methylation may be involved in esophageal tumorigenesis. This gene is adjacent to another family member CLDN9 on chromosome 16.Synonyms: PRO1488, Skullin, Skullin 2, UNQ757

Molecular Weight: 23292 Da

Gene ID: 9074

NCBI Accession: NP_067018

Pathways: Hepatitis C