COCH antibody (C-Term)

Catalog No. ABIN951613

This Rabbit Polyclonal antibody specifically detects COCH in WB and EIA. It exhibits reactivity toward Human.

Quick Overview for COCH antibody (C-Term) (ABIN951613)

Target: COCH (Cochlin (COCH))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This COCH antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Product Details anti-COCH Antibody

Binding Specificity: AA 499-528, C-Term

Specificity: This antibody reacts to COCH.

Cross-Reactivity (Details): Species reactivity (tested):Human.

Purification: Affinity chromatography on Protein A

Immunogen: KLH conjugated synthetic peptide between 499-528 amino acids from the C-terminal region of human COCH

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS, 0.09 % (W/V) sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for COCH

Target: COCH (Cochlin (COCH))

Alternative Name: Cochlin

Background: The protein encoded by this gene is highly conserved in human, mouse, and chicken, showing 94 % and 79 % amino acid identity of human to mouse and chicken sequences, respectively. Hybridization to this gene was detected in spindle-shaped cells located along nerve fibers between the auditory ganglion and sensory epithelium. These cells accompany neurites at the habenula perforata, the opening through which neurites extend to innervate hair cells. This and the pattern of expression of this gene in chicken inner ear paralleled the histologic findings of acidophilic deposits, consistent with mucopolysaccharide ground substance, in temporal bones from DFNA9 (autosomal dominant nonsyndromic sensorineural deafness 9) patients. Mutations that cause DFNA9 have been reported in this gene. Alternative splicing results in multiple transcript variants encoding the same protein. Additional splice variants encoding distinct isoforms have been described but their biological validities have not been demonstrated. [provided by RefSeq].Synonyms: COCH, COCH-5B2, COCH5B2

Molecular Weight: 59483 Da

Gene ID: 1690

NCBI Accession: NP_001128530

Pathways: Sensory Perception of Sound