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COCH antibody

COCH Reactivity: Human IHC, IF Host: Rabbit Polyclonal unconjugated
Catalog No. ABIN7262425
  • Target See all COCH Antibodies
    COCH (Cochlin (COCH))
    Reactivity
    • 47
    • 13
    • 5
    • 4
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    Human
    Host
    • 45
    • 2
    Rabbit
    Clonality
    • 47
    Polyclonal
    Conjugate
    • 20
    • 5
    • 4
    • 4
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This COCH antibody is un-conjugated
    Application
    • 37
    • 27
    • 15
    • 13
    • 2
    • 2
    • 2
    Immunohistochemistry (IHC), Immunofluorescence (IF)
    Characteristics
    Polyclonal Antibody
    Purification
    Affinity purification
    Immunogen
    Recombinant fusion protein of human COCH (NP_001128530.1).
    Isotype
    IgG
    Top Product
    Discover our top product COCH Primary Antibody
  • Application Notes
    IHC 1:50-1:100 IF 1:50-1:100
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 mg/mL
    Buffer
    PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
    Preservative
    Sodium azide
    Precaution of Use
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    COCH (Cochlin (COCH))
    Alternative Name
    COCH (COCH Products)
    Synonyms
    AW122937 antibody, Coch-5B2 antibody, D12H14S564E antibody, COCH-5B2 antibody, COCH5B2 antibody, DFNA9 antibody, cochlin antibody, Coch antibody, COCH antibody
    Background
    The protein encoded by this gene is highly conserved in human, mouse, and chicken, showing 94 % and 79 % amino acid identity of human to mouse and chicken sequences, respectively. Hybridization to this gene was detected in spindle-shaped cells located along nerve fibers between the auditory ganglion and sensory epithelium. These cells accompany neurites at the habenula perforata, the opening through which neurites extend to innervate hair cells. This and the pattern of expression of this gene in chicken inner ear paralleled the histologic findings of acidophilic deposits, consistent with mucopolysaccharide ground substance, in temporal bones from DFNA9 (autosomal dominant nonsyndromic sensorineural deafness 9) patients. Mutations that cause DFNA9 have been reported in this gene. Alternative splicing results in multiple transcript variants encoding the same protein. Additional splice variants encoding distinct isoforms have been described but their biological validities have not been demonstrated.
    Gene ID
    1690
    UniProt
    O43405
    Pathways
    Sensory Perception of Sound
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