CXXC1 antibody (Middle Region)

Catalog No. ABIN951679

Product Details anti-CXXC1 Antibody

Target: CXXC1 (CXXC Finger Protein 1 (CXXC1))

Binding Specificity: AA 325-354, Middle Region

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CXXC1 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificity: This antibody detects CpG-binding protein/CXXC1 (Center).

Cross-Reactivity (Details): Species reactivity (tested):Human, Mouse

Purification: Purified through a protein A column; followed by peptide affinity purification.

Immunogen: KLH conjugated synthetic peptide from the central region (between 325-354 aa) of Human CpG-binding protein/CXXC1.

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) Sodium Azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for CXXC1

Target: CXXC1 (CXXC Finger Protein 1 (CXXC1))

Alternative Name: CpG-Binding Protein (CXXC1 Products)

Synonyms: LWS-2 antibody, opn1lw2 antibody, zgc:55527 antibody, 2410002I16Rik antibody, 5830420C16Rik antibody, AI426635 antibody, Cfp1 antibody, Cgbp antibody, PHF18 antibody, CFP1 antibody, CGBP antibody, HsT2645 antibody, PCCX1 antibody, SPP1 antibody, ZCGPC1 antibody, hCGBP antibody, CXXC-type zinc finger protein 1 antibody, CXXC finger protein 1 antibody, CXXC finger protein 1b antibody, CXXC finger 1 (PHD domain) antibody, CXXC finger protein 1 S homeolog antibody, LOC5575222 antibody, CXXC1 antibody, cxxc1b antibody, Cxxc1 antibody, cxxc1.S antibody

Background: Human CpG binding protein (hCGBP) contains three cysteine-rich domains, two of which exhibit homology to the plant homeodomain finger domain and the third cysteine-rich domain conforms to the CXXC motif identified in DNA methyltransferase, human trithorax, and methyl-CpG binding domain protein 1. A fragment of hCGBP that contains the CXXC domain binds to an oligonucleotide probe containing a single CpG site, and this complex is disrupted by distinct oligonucleotide competitors that also contain a CpG motif(s). CBGP plays an important part in embryonic viability and peri-implantation development. Native hCGBP is detected as an 88- kDa protein by Western analysis and is ubiquitously expressed. CGBP trans-activates promoters that contain CpG motifs but not promoters in which the CpG is ablated suggesting that hCGBP is a transcriptional activator that recognizes unmethylated CpG dinucleotides.Synonyms: CFP1, CGBP, CXXC-type zinc finger protein 1, CXXC1, PCCX1, PHD finger and CXXC domain-containing protein 1, PHF18

Gene ID: 30827

NCBI Accession: NP_001095124

Pathways: ER-Nucleus Signaling