FYB antibody (FYN-Binding Protein) (C-Term)

Details for Product anti-FYB Antibody No. ABIN952408, Supplier: Log in to see
Antigen
  • fyb
  • ADAP
  • PRO0823
  • SLAP-130
  • B630013F22Rik
  • FYB-120/130
  • Slap130
  • p120/130
  • p120/p130
  • RGD1563421
  • FYN-binding protein
  • FYN binding protein 1
  • FYN binding protein
  • fyb
  • FYB1
  • Fyb
  • Fyb1
Alternatives
anti-Human FYB antibody for Western Blotting
Epitope
C-Term, AA 645-675
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Reactivity
Human
92
27
21
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Host
Rabbit
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10
2
Clonality
Polyclonal
Conjugate
This FYB antibody is un-conjugated
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1
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Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
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41
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Options
Supplier
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Supplier Product No.
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Immunogen KLH conjugated synthetic peptide between 645-675 amino acids from the C-terminal region of Human FYN-binding protein Genename: FYB
Isotype Ig Fraction
Specificity This antibody recognizes Human FYN-binding protein (C-term).
Purification Protein A column, followed by peptide affinity purification
Alternative Name FYN-Binding Protein (FYB Antibody Abstract)
Background FYB acts as an adapter protein of the FYN and LCP2 signaling cascades in T cells. Modulates the expression of interleukin-2 (IL-2). Involved in platelet activation. Prevents the degradation of SKAP1 and SKAP2.Synonyms: Adhesion and degranulation promoting adaptor protein, FYB-120/130, FYN-T-binding protein, SLAP-130, SLAP130, SLP-76-associated phosphoprotein, p120/p130
Molecular Weight 85387 Da
Gene ID 2533
NCBI Accession NP_955367
Pathways TCR Signaling, Protein targeting to Nucleus
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL
Buffer PBS containing 0.09 % (W/V) Sodium Azide as preservative
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Western Blotting (WB) image for anti-FYN-Binding Protein (FYB) (AA 645-675), (C-Term) antibody (ABIN952408) Western blot analysis of FYB Antibody (C-term) Cat.-No AP51746PU-N  in MDA-MB435 cell...
Background publications Srivastava, Burbach, Shimizu: "NF-kappaB activation in T cells requires discrete control of IkappaB kinase alpha/beta (IKKalpha/beta) phosphorylation and IKKgamma ubiquitination by the ADAP adapter protein." in: The Journal of biological chemistry, Vol. 285, Issue 15, pp. 11100-5, 2010 (PubMed).

Lehmann, Meyer, Schuemann, Krause, Freund: "A novel S3S-TAP-tag for the isolation of T-cell interaction partners of adhesion and degranulation promoting adaptor protein." in: Proteomics, Vol. 9, Issue 23, pp. 5288-95, 2009 (PubMed).

Hanna, Kruskal, Ezekowitz, Bloom, Collier: "Role of macrophage oxidative burst in the action of anthrax lethal toxin." in: Molecular medicine (Cambridge, Mass.), Vol. 1, Issue 1, pp. 7-18, 1996 (PubMed).

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