CRYGB antibody (Middle Region)

Catalog No. ABIN952455

The Rabbit Polyclonal anti-CRYGB antibody (ABIN952455) specifically detects CRYGB in WB and EIA. The antibody is reactive with Human samples.

Quick Overview for CRYGB antibody (Middle Region) (ABIN952455)

Target: CRYGB (Crystallin, gamma B (CRYGB))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CRYGB antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Product Details anti-CRYGB Antibody

Binding Specificity: AA 67-97, Middle Region

Specificity: This antibody recognizes Human Gamma-crystallin B (Center).

Purification: Affinity Chromatography on Protein A

Immunogen: KLH conjugated synthetic peptide between 67-97 amino acids from the Central region of Human CRYGB. Genename: CRYGB

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS, 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for CRYGB

Target: CRYGB (Crystallin, gamma B (CRYGB))

Alternative Name: gamma-Crystallin B

Background: Crystallins are separated into two classes: taxon-specific, or enzyme, and ubiquitous. The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of the lens. Since lens central fiber cells lose their nuclei during development, these crystallins are made and then retained throughout life, making them extremely stable proteins. Mammalian lens crystallins are divided into alpha, beta, and gamma families, beta and gamma crystallins are also considered as a superfamily. Alpha and beta families are further divided into acidic and basic groups. Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Gamma-crystallins are a homogeneous group of highly symmetrical, monomeric proteins typically lacking connecting peptides and terminal extensions. They are differentially regulated after early development. Four gamma-crystallin genes (gamma-A through gamma-D) and three pseudogenes (gamma-E, gamma-F, gamma-G) are tandemly organized in a genomic segment as a gene cluster. Whether due to aging or mutations in specific genes, gamma-crystallins have been involved in cataract formation.Synonyms: CRYG2, CRYGB, Gamma-B-crystallin, Gamma-crystallin 1-2

Gene ID: 1419

NCBI Accession: NP_005201