GRPR antibody (Middle Region)

Catalog No. ABIN952465

This Rabbit Polyclonal antibody specifically detects GRPR in WB, FACS and IHC (p). It exhibits reactivity toward Human.

Quick Overview for GRPR antibody (Middle Region) (ABIN952465)

Target: GRPR (Gastrin-Releasing Peptide Receptor (GRPR))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GRPR antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-GRPR Antibody

Binding Specificity: AA 130-160, Middle Region

Specificity: This antibody recognizes Human Gastrin-releasing peptide receptor (Center).

Purification: Protein A column, followed by peptide affinity purification

Immunogen: KLH conjugated synthetic peptide between 130~160 amino acids from the Central region of Human Gastrin-releasing peptide receptor Genename: GRPR

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS containing 0.09 % (W/V) Sodium Azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for GRPR

Target: GRPR (Gastrin-Releasing Peptide Receptor (GRPR))

Alternative Name: Gastrin-Releasing Peptide Receptor

Background: Gastrin-releasing peptide (GRP) regulates numerous functions of the gastrointestinal and central nervous systems, including release of gastrointestinal hormones, smooth muscle cell contraction, and epithelial cell proliferation and is a potent mitogen for neoplastic tissues. The effects of GRP are mediated through the gastrin-releasing peptide receptor. This receptor is a glycosylated, 7-transmembrane G-protein coupled receptor that activates the phospholipase C signaling pathway. The receptor is aberrantly expressed in numerous cancers such as those of the lung, colon, and prostate. An individual with autism and multiple exostoses was found to have a balanced translocation between chromosome 8 and a chromosome X breakpoint located within the gastrin-releasing peptide receptor gene.Synonyms: GRP-R, GRP-preferring bombesin receptor, GRPR

Molecular Weight: 43199 Da

Gene ID: 2925

NCBI Accession: NP_005305