HFE2 antibody (Middle Region)

Catalog No. ABIN952727

The Rabbit Polyclonal anti-HFE2 antibody is suitable to detect HFE2 in samples from Human and Mouse. It has been validated for WB and IHC (p).

Quick Overview for HFE2 antibody (Middle Region) (ABIN952727)

Target: HFE2 (Hemochromatosis Type 2 (Juvenile) (HFE2))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HFE2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-HFE2 Antibody

Binding Specificity: AA 141-170, Middle Region

Specificity: This antibody recognizes Human and Mouse HFE2 / Hemojuvelin (Center).

Purification: Protein A column, followed by peptide affinity purification

Immunogen: KLH conjugated synthetic peptide between 141~170 amino acids from the Central region of Human HFE2 / Hemojuvelin

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS containing 0.09 % (W/V) Sodium Azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for HFE2

Target: HFE2 (Hemochromatosis Type 2 (Juvenile) (HFE2))

Alternative Name: HFE2 / Hemojuvelin

Background: HFE2 is involved in iron metabolism. It may be a component of the signaling pathway which activates hepcidin or it may act as a modulator of hepcidin expression. It could also represent the cellular receptor for hepcidin.Synonyms: HJV, Hemochromatosis type 2 protein, RGM domain family member C, RGMC

Molecular Weight: 45080 Da

Gene ID: 148738

NCBI Accession: NP_660320

Pathways: Transition Metal Ion Homeostasis