EPAS1 antibody (N-Term)

Catalog No. ABIN952733

The Rabbit Polyclonal anti-EPAS1 antibody has been validated for WB, FACS and EIA. It is suitable to detect EPAS1 in samples from Human.

Quick Overview for EPAS1 antibody (N-Term) (ABIN952733)

Target: EPAS1 (Endothelial PAS Domain Protein 1 (EPAS1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This EPAS1 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Enzyme Immunoassay (EIA)

Product Details anti-EPAS1 Antibody

Binding Specificity: AA 127-154, N-Term

Specificity: This antibody recognizes Human HIF2A / HIF2 alpha (N-term).

Purification: Affinity Chromatography on Protein A

Immunogen: KLH conjugated synthetic peptide between 127-154 amino acids from the N-terminal region of Human HIF2A Genename: EPAS1

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS containing 0.09 % (W/V) Sodium Azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for EPAS1

Target: EPAS1 (Endothelial PAS Domain Protein 1 (EPAS1))

Alternative Name: HIF2A / HIF2 alpha

Background: This gene encodes a transcription factor involved in the induction of genes regulated by oxygen, which is induced as oxygen levels fall. The encoded protein contains a basic-helix-loop-helix domain protein dimerization domain as well as a domain found in proteins in signal transduction pathways which respond to oxygen levels. Mutations in this gene are associated with erythrocytosis familial type 4.Synonyms: BHLHE73, Basic-helix-loop-helix-PAS protein MOP2, Class E basic helix-loop-helix protein 73, EPAS1, Endothelial PAS domain-containing protein 1, HIF-1 alpha-like factor, HIF-2 alpha, HIF-related factor, HLF, Hypoxia-inducible factor 2 alpha, MOP2, PASD2

Molecular Weight: 96459 Da

Gene ID: 2034

NCBI Accession: NP_001421

Pathways: Signaling Events mediated by VEGFR1 and VEGFR2, Warburg Effect