KNG1 antibody (N-Term)

Catalog No. ABIN953079

The Rabbit Polyclonal anti-KNG1 antibody (ABIN953079) specifically detects KNG1 in WB, FACS, IHC (p) and EIA. The antibody is reactive with Human samples.

Quick Overview for KNG1 antibody (N-Term) (ABIN953079)

Target: KNG1 (Kininogen 1 (KNG1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KNG1 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Product Details anti-KNG1 Antibody

Binding Specificity: AA 145-174, N-Term

Specificity: This antibody recognizes Human Kininogen-1 (N-term).

Purification: Protein A column, followed by peptide affinity purification

Immunogen: KLH conjugated synthetic peptide between 145-174 amino acids from the N-terminal region of Human Kininogen-1 Genename: KNG1

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS containing 0.09 % (W/V) Sodium Azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for KNG1

Target: KNG1 (Kininogen 1 (KNG1))

Alternative Name: Kininogen-1

Background: This gene uses alternative splicing to generate two different proteins- high molecular weight kininogen (HMWK) and low molecular weight kininogen (LMWK). HMWK is essential for blood coagulation and assembly of the kallikrein-kinin system. Also, bradykinin, a peptide causing numerous physiological effects, is released from HMWK. In contrast to HMWK, LMWK is not involved in blood coagulation. Three transcript variants encoding different isoforms have been found for this gene.Synonyms: Alpha-2-thiol proteinase inhibitor, BDK, Fitzgerald factor, High molecular weight kininogen, KNG, KNG1, Williams-Fitzgerald-Flaujeac factor

Molecular Weight: 71957 Da

Gene ID: 3827

NCBI Accession: NP_000884

Pathways: ACE Inhibitor Pathway, Glycosaminoglycan Metabolic Process