MRGPRX2 antibody (C-Term)

Catalog No. ABIN953498

Product Details anti-MRGPRX2 Antibody

Target: MRGPRX2 (G Protein-Coupled Receptor MRGX2 (MRGPRX2))

Binding Specificity: AA 286-316, C-Term

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MRGPRX2 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificity: This antibody recognizes MRGPRX2 at C-term.

Cross-Reactivity (Details): Species reactivity (tested):Human

Purification: Purified through a Protein A column followed by peptide affinity purification

Immunogen: Synthetic peptide - KLH conjugated - corresponding to the C-terminal region (between 286-316aa) of human MRGPRX2.

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) Sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for MRGPRX2

Target: MRGPRX2 (G Protein-Coupled Receptor MRGX2 (MRGPRX2))

Alternative Name: MRGPRX2 (MRGPRX2 Products)

Background: MRGPRX2 is the orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Cortistatin-14 seems to be a high potency ligand at this receptor. Cortistatin has several biological functions including roles in sleep regulation locomotor activity, and cortical function. In receptor-expressing cells, cortistatin-stimulated increases in intracellular Ca(2+) but had no effect on basal or forskolin-stimulated cAMP levels, suggesting that this receptor is G(q)-coupled.Synonyms: MRGX2, Mas-related G-protein coupled receptor member X2

Gene ID: 117194

NCBI Accession: NP_473371