MXI1 antibody (Middle Region)

Catalog No. ABIN953554

Product Details anti-MXI1 Antibody

Target: MXI1 (MAX Interactor 1 (MXI1))

Binding Specificity: AA 52-82, Middle Region

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MXI1 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Specificity: This antibody recognizes human and mouse MXI1.

Purification: Purified through a Protein A column followed by peptide affinity purification

Immunogen: Synthetic peptide - KLH conjugated - corresponding to the central region (between 52-82aa) of human MXI1.

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) Sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for MXI1

Target: MXI1 (MAX Interactor 1 (MXI1))

Alternative Name: MXI1 (MXI1 Products)

Synonyms: mxi antibody, mad2 antibody, mxd2 antibody, xmxi1 antibody, MGC89544 antibody, MXI1 antibody, etID309773.22 antibody, fb16b12 antibody, fb55f03 antibody, wu:fb16b12 antibody, wu:fb55f03 antibody, wu:fd06a08 antibody, wu:fz74f10 antibody, ENSMUSG00000067085 antibody, Gm10197 antibody, Mad2 antibody, bHLHc11 antibody, MXI-WR antibody, MAD2 antibody, MXD2 antibody, MXI antibody, MAX interactor 1, dimerization protein antibody, max interactor 1, dimerization protein antibody, MAX interactor 1, dimerization protein L homeolog antibody, mxi1 antibody, MXI1 antibody, Mxi1 antibody, mxi1.L antibody

Background: Expression of the c-myc gene, which produces an oncogenic transcription factor, is tightly regulated in normal cells but is frequently deregulated in human cancers. The protein encoded by this gene is a transcriptional repressor thought to negatively regulate MYC function, and is therefore a potential tumor suppressor. This protein inhibits the transcriptional activity of MYC by competing for MAX, another basic helix-loop-helix protein that binds to MYC and is required for its function. Defects in this gene are frequently found in patients with prostate tumors. Three alternatively spliced transcripts encoding different isoforms have been described. Additional alternatively spliced transcripts may exist but the products of these transcripts have not been verified experimentally.Synonyms: Class C basic helix-loop-helix protein 11, MAX-interacting protein 1, Max interactor 1, bHLHc11

Molecular Weight: 26062 Da

Gene ID: 4601

NCBI Accession: NP_005953

Pathways: Maintenance of Protein Location