NUDT15 antibody (C-Term)

Catalog No. ABIN953779

Product Details anti-NUDT15 Antibody

Target: NUDT15 (Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 15 (NUDT15))

Binding Specificity: AA 89-118, C-Term

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NUDT15 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificity: This antibody recognizes NUDT15.

Cross-Reactivity (Details): Species reactivity (tested):Human, Mouse

Purification: Purified through a Protein A column followed by peptide affinity purification

Immunogen: Synthetic peptide - KLH conjugated - corresponding to the C-terminal region (between 89-118aa) of human NUDT15.

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) Sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for NUDT15

Target: NUDT15 (Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 15 (NUDT15))

Alternative Name: NUDT15 (NUDT15 Products)

Synonyms: MTH2 antibody, RP11-90M2.1 antibody, 6530403O17 antibody, A730068G11Rik antibody, nudix hydrolase 15 antibody, nudix (nucleoside diphosphate linked moiety X)-type motif 15 antibody, NUDT15 antibody, Nudt15 antibody

Background: Mediates the hydrolysis of some nucleoside diphosphate derivatives. Can degrade 8-oxo-dGTP in vitro, suggesting that it may remove an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine) from DNA and the nucleotide pool, thereby preventing misincorporation of 8-oxo-dGTP into DNA thus preventing A:T to C:G transversions. Its substrate specificity in vivo however remains unclear (By similarity). May have a role in DNA synthesis and cell cycle progression throught the interaction with PCNA.Synonyms: 7, 8-dihydro-8-oxoguanine-triphosphatase NUDT15, MTH2, MutT homolog 2, Nucleoside diphosphate-linked moiety X motif 15, Nudix motif 15, Probable 8-oxo-dGTP diphosphatase NUDT15

Gene ID: 55270

NCBI Accession: NP_060753