NUDT15 antibody (AA 1-164) (FITC)

Catalog No. ABIN7162071

Product Details anti-NUDT15 Antibody (FITC)

Target: NUDT15 (Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 15 (NUDT15))

Binding Specificity: AA 1-164

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This NUDT15 antibody is conjugated to FITC

Application: Please inquire

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Nucleotide triphosphate diphosphatase NUDT15 protein (1-164AA)

Isotype: IgG

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, pH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for NUDT15

Target: NUDT15 (Nudix (Nucleoside Diphosphate Linked Moiety X)-Type Motif 15 (NUDT15))

Alternative Name: NUDT15 (NUDT15 Products)

Synonyms: MTH2 antibody, RP11-90M2.1 antibody, 6530403O17 antibody, A730068G11Rik antibody, nudix hydrolase 15 antibody, nudix (nucleoside diphosphate linked moiety X)-type motif 15 antibody, NUDT15 antibody, Nudt15 antibody

Background:

Background: May catalyze the hydrolysis of nucleoside triphosphates including dGTP, dTTP, dCTP, their oxidized forms like 8-oxo-dGTP and the prodrug thiopurine derivatives 6-thio-dGTP and 6-thio-GTP (PubMed:26238318). Could also catalyze the hydrolysis of some nucleoside diphosphate derivatives (PubMed:22556419, PubMed:26238318). Hydrolyzes oxidized nucleosides triphosphates like 8-oxo-dGTP in vitro, but the specificity and efficiency towards these substrates are low. Therefore, the potential in vivo sanitizing role of this enzyme, that would consist in removing oxidatively damaged forms of nucleosides to prevent their incorporation into DNA, is unclear (PubMed:26238318, PubMed:22556419). Through the hydrolysis of thioguanosine triphosphates may participate in the catabolism of thiopurine drugs (PubMed:26238318, PubMed:25108385). May also have a role in DNA synthesis and cell cycle progression by stabilizing PCNA (PubMed:19419956).

Aliases: 8-dihydro-8-oxoguanine triphosphatase NUDT15 antibody, 8-oxo-dGTPase NUDT15 antibody, A730068G11Rik antibody, EC 3.1.6.- antibody, FLJ10956 antibody, MGC104352 antibody, MTH2 antibody, MutT homolog 2 antibody, Nucleoside diphosphate-linked moiety X motif 15 antibody, NUD15_HUMAN antibody, Nudix (nucleoside diphosphate linked moiety X)-type motif antibody, Nudix motif 15 antibody, NUDT15 antibody, OTTHUMP00000018389 antibody, Probable 7 antibody, Probable 7,8-dihydro-8-oxoguanine triphosphatase NUDT15 antibody, RP11-90M2.1 antibody

UniProt: Q9NV35