PDZK1 antibody (Middle Region)

Catalog No. ABIN954079

This Rabbit Polyclonal antibody specifically detects PDZK1 in WB, IHC (p) and EIA. It exhibits reactivity toward Human.

Quick Overview for PDZK1 antibody (Middle Region) (ABIN954079)

Target: PDZK1 (PDZ Domain Containing 1 (PDZK1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PDZK1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Product Details anti-PDZK1 Antibody

Binding Specificity: AA 195-224, Middle Region

Specificity: This antibody recognizes Human PDZK1 (Center).

Purification: Protein A column, followed by peptide affinity purification

Immunogen: KLH conjugated synthetic peptide between 195-224 amino acids from the Central region of human PDZK1

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS containing 0.09 % (W/V) Sodium Azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for PDZK1

Target: PDZK1 (PDZ Domain Containing 1 (PDZK1))

Alternative Name: PDZD1

Background: A scaffold protein that connects plasma membrane proteins and regulatory components, regulating their surface expression in epithelial cells apical domains. May be involved in the coordination of a diverse range of regulatory processes for ion transport and second messenger cascades. In complex with SLC9A3R1, may cluster proteins that are functionally dependent in a mutual fashion and modulate the trafficking and the activity of the associated membrane proteins. May play a role in the cellular mechanisms associated with multidrug resistance through its interaction with ABCC2 and PDZK1IP1. May potentiate the CFTR chloride channel activity. May function to connect SCARB1 with the cellular machineries for intracellular cholesterol transport and/or metabolism. May be involved in the regulation of proximal tubular Na(+)-dependent inorganic phosphate cotransport therefore playing an important role in tubule function (By similarity).Synonyms: CAP70, NHE-RF3, NHERF-3, NHERF3, Na(+)/H(+) exchange regulatory cofactor NHE-RF3, NaPi-Cap1, PDZ domain-containing protein 1, PDZK1, Sodium-hydrogen exchanger regulatory factor 3

Molecular Weight: 57129 Da

Gene ID: 5174

NCBI Accession: NP_001188254