PNN antibody (Middle Region)

Catalog No. ABIN954147

This anti-PNN antibody is a Rabbit Polyclonal antibody detecting PNN in WB, IF, IHC (p) and EIA. Suitable for Human.

Quick Overview for PNN antibody (Middle Region) (ABIN954147)

Target: PNN (Pinin, Desmosome Associated Protein (PNN))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PNN antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Product Details anti-PNN Antibody

Binding Specificity: AA 216-248, Middle Region

Specificity: This antibody recognizes Human Pinin / PNN (Center).

Purification: Affinitty Chromatography on Protein A

Immunogen: KLH conjugated synthetic peptide between 216-248 amino acids from the Central region of human PNN.

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS containing 0.09 % (W/V) Sodium Azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for PNN

Target: PNN (Pinin, Desmosome Associated Protein (PNN))

Alternative Name: Pinin / PNN

Background: Transcriptional activator binding to the E-box 1 core sequence of the E-cadherin promoter gene, the core-binding sequence is 5'CAGGTG-3'. Capable of reversing CTBP1-mediated transcription repression. Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Participates in the regulation of alternative pre-mRNA splicing. Associates to spliced mRNA within 60 nt upstream of the 5'-splice sites. Involved in the establishment and maintenance of epithelia cell-cell adhesion. Potential tumor suppressor for renal cell carcinoma.Synonyms: 140 kDa nuclear and cell adhesion-related phosphoprotein, DRS, DRSP, Desmosome-associated protein, Domain-rich serine protein, MEMA, Nuclear protein SDK3

Molecular Weight: 81614 Da

Gene ID: 5411

NCBI Accession: NP_002678