PROC antibody

Catalog No. ABIN954315

The Mouse Monoclonal anti-PROC antibody (Clone CaC-11) (ABIN954315) specifically detects PROC in WB and EIA. The antibody is reactive with Human samples.

Quick Overview for PROC antibody (ABIN954315)

Target: PROC (Vitamin K-dependent protein C (PROC))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This PROC antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Clone: CaC-11

Product Details anti-PROC Antibody

Specificity: This antibody is specific for Human Protein C/APC in the presence of 5-10 mM CaCl2.

Purification: Affinity chromatography on Protein G

Immunogen: Human Protein C purified from the supernatant of thrombin activated platelets.

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 1,0 mg/mL

Buffer: PBS containing 0.02 % Sodium Azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for PROC

Target: PROC (Vitamin K-dependent protein C (PROC))

Alternative Name: Protein C / PROC

Background: Protein C (PC) is a major physiological anticoagulant, and an important regulator of the blood coagulation system. PC is a vitamin K dependent serine protease enzyme that is activated by thrombin. The anticoagulant PC is converted to activated protein C (APC) by the thrombomodulin (TM) - thrombin complex on the phospholipid surface of endothelial cells, monocytes and platelets. APC degrades coagulation Factors Va and VIIIa rendering these factors inactive. APC provides physiologic antithrombotic activity and exhibits both anti-inflammatory and anti-apoptotic activity. Treatment with APC has been shown to improve the clinical outcome of patients with sepsis.Synonyms: Anticoagulant protein C, Autoprothrombin IIA, Blood coagulation factor XIV, Inactivator of coagulation factors Va and VIIIa, PROC1, Vitamin K-dependent protein C

Gene ID: 5624

NCBI Accession: NP_000303

UniProt: P04070