PTPN22 antibody (C-Term)

Catalog No. ABIN954376

This Rabbit Polyclonal antibody specifically detects PTPN22 in WB and EIA. It exhibits reactivity toward Human.

Quick Overview for PTPN22 antibody (C-Term) (ABIN954376)

Target: PTPN22 (Tyrosine-Protein Phosphatase Non-Receptor Type 22 (PTPN22))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PTPN22 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Product Details anti-PTPN22 Antibody

Binding Specificity: AA 662-691, C-Term

Specificity: This antibody recognizes PTPN22 at C-term.

Cross-Reactivity (Details): Species reactivity (tested):Human

Purification: Purified through a Protein A column followed by peptide affinity purification

Immunogen: Synthetic peptide - KLH conjugated - corresponding to the C-terminal region (between 662-691aa) of human PTPN22.

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) Sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for PTPN22

Target: PTPN22 (Tyrosine-Protein Phosphatase Non-Receptor Type 22 (PTPN22))

Alternative Name: PTPN22

Background: The PTPN22 gene encodes of member of the non-receptor class 4 subfamily of the protein-tyrosine phosphatase family. The encoded protein is a lymphoid-specific intracellular phosphatase that associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T-cell receptor signaling pathway. Mutations in this gene may be associated with a range of autoimmune disorders including Type 1 Diabetes, rheumatoid arthritis, systemic lupus erythematosus and Graves' disease. Alternatively spliced transcript variants encoding distinct isoforms have been described.Synonyms: Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP, LYP1, LYP2, LyP, Lymphoid phosphatase, PEP, PTPN8, Tyrosine-protein phosphatase non-receptor type 22

Gene ID: 26191

NCBI Accession: NP_001180360