Importin 11 antibody (C-Term)

Catalog No. ABIN954448

This Rabbit Polyclonal antibody specifically detects Importin 11 in WB and EIA. It exhibits reactivity toward Human.

Quick Overview for Importin 11 antibody (C-Term) (ABIN954448)

Target: Importin 11 (IPO11)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Importin 11 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Product Details anti-Importin 11 Antibody

Binding Specificity: AA 906-970, C-Term

Specificity: This antibody recognizes Human RanBP11 / Importin-11 (C-term).

Purification: Protein A column, followed by peptide affinity purification

Immunogen: KLH conjugated synthetic peptide between 906~970 amino acids from the C-terminal region of Human RanBP11 / Importin-11 Genename: IPO11

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS containing 0.09 % (W/V) Sodium Azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for Importin 11

Target: Importin 11 (IPO11)

Alternative Name: RanBP11 / Importin-11

Background: IPO11 functions in nuclear protein import as nuclear transport receptor. It serves as receptor for nuclear localization signals (NLS) in cargo substrates and is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP-and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). It mediates the nuclear import of UBE2E3, and of RPL12 (By similarity).Synonyms: IPO11, Imp11, Ran-binding protein 11

Molecular Weight: 112535 Da

Gene ID: 51194

NCBI Accession: NP_001128251

Pathways: Protein targeting to Nucleus