SPR antibody (C-Term)

Catalog No. ABIN954723

The Rabbit Polyclonal anti-SPR antibody (ABIN954723) specifically detects SPR in WB and EIA. The antibody is reactive with Human and Mouse samples.

Quick Overview for SPR antibody (C-Term) (ABIN954723)

Target: SPR (Sepiapterin Reductase (SPR))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SPR antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Product Details anti-SPR Antibody

Binding Specificity: AA 232-261, C-Term

Specificity: This antibody recognizes Sepiapterin reductase / SPRat N-term.

Cross-Reactivity (Details): Species reactivity (tested):Human, Mouse

Purification: Purified through a Protein A column followed by peptide affinity purification

Immunogen: Synthetic peptide - KLH conjugated - corresponding to the C-terminal region (between 232-261aa) of human Sepiapterin reductase / SPR.

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) Sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for SPR

Target: SPR (Sepiapterin Reductase (SPR))

Alternative Name: Sepiapterin Reductase / SPR

Background: The SPR gene encodes an aldo-keto reductase that catalyzes the NADPH-dependent reduction of pteridine derivatives and is important in the biosynthesis of tetrahydrobiopterin (BH4). Mutations in this gene result in DOPA-responsive dystonia due to sepiapterin reductase deficiency. A pseudogene has been identified on chromosome 1.Synonyms: EC 1.1.1.153, SDR38C1, short chain dehydrogenase/reductase family 38C member 1

Gene ID: 6697

NCBI Accession: NP_003115

Pathways: Regulation of Systemic Arterial Blood Pressure by Hormones, Feeding Behaviour, Smooth Muscle Cell Migration