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AANAT antibody (N-Term)
AANAT
Reactivity: Human
WB, EIA
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-AANAT Antibody
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Target
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AANAT
(Aralkylamine N-Acetyltransferase (AANAT))
Binding Specificity
All epitopes for AANAT antibodies
AA 33-63, N-Term
Reactivity
All reactivities for AANAT antibodies
Human
Host
All hosts for AANAT antibodies
Rabbit
Clonality
All clonalities for AANAT antibodies
Polyclonal
Conjugate
All conjugates for AANAT antibodies
This AANAT antibody is un-conjugated
Application
All applications for AANAT antibodies
Western Blotting (WB), Enzyme Immunoassay (EIA)
Specificity
This antibody reacts to Serotonin acetylase.
Cross-Reactivity (Details)
Species reactivity (tested):Human.
Purification
Affinity chromatography on Protein A
Immunogen
KLH conjugated synthetic peptide between 33~63 amino acids from the N-terminal region of human AANAT
Isotype
Ig Fraction
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Alternatives
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Application Details
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Application Notes
Optimal working dilution should be determined by the investigator.
Restrictions
For Research Use only
Handling
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Format
Liquid
Concentration
0.25 mg/mL
Buffer
PBS containing 0.09 % (W/V) sodium azide as preservative
Preservative
Sodium azide
Precaution of Use
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Avoid repeated freezing and thawing.
Storage
4 °C/-20 °C
Storage Comment
Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Target Details for AANAT
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Target
AANAT
(Aralkylamine N-Acetyltransferase (AANAT))
Alternative Name
Serotonin Acetylase (AANAT Products )
Synonyms
DSPS antibody, SNAT antibody, AA-NAT antibody, Nat4 antibody, Nat-2 antibody, Snat antibody, aralkylamine N-acetyltransferase antibody, arylalkylamine N-acetyltransferase antibody, AANAT antibody, Aanat antibody
Background
AANAT belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity and sleep. This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the enzyme against proteasomal degradation. This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome.Synonyms: AA-NAT, AANAT, Aralkylamine N-acetyltransferase, SNAT, Serotonin N-acetyltransferase
Gene ID
15
NCBI Accession
NP_001079
Pathways
Photoperiodism
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