AANAT antibody (N-Term)

Catalog No. ABIN954733

This Rabbit Polyclonal antibody specifically detects AANAT in WB and EIA. It exhibits reactivity toward Human.

Quick Overview for AANAT antibody (N-Term) (ABIN954733)

Target: AANAT (Aralkylamine N-Acetyltransferase (AANAT))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This AANAT antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Product Details anti-AANAT Antibody

Binding Specificity: AA 33-63, N-Term

Specificity: This antibody reacts to Serotonin acetylase.

Cross-Reactivity (Details): Species reactivity (tested):Human.

Purification: Affinity chromatography on Protein A

Immunogen: KLH conjugated synthetic peptide between 33~63 amino acids from the N-terminal region of human AANAT

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS containing 0.09 % (W/V) sodium azide as preservative

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Target Details for AANAT

Target: AANAT (Aralkylamine N-Acetyltransferase (AANAT))

Alternative Name: Serotonin Acetylase

Background: AANAT belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity and sleep. This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the enzyme against proteasomal degradation. This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome.Synonyms: AA-NAT, AANAT, Aralkylamine N-acetyltransferase, SNAT, Serotonin N-acetyltransferase

Gene ID: 15

NCBI Accession: NP_001079

Pathways: Photoperiodism