Transferrin Receptor 2 antibody (C-Term)

Catalog No. ABIN955173

The Rabbit Polyclonal anti-Transferrin Receptor 2 antibody (ABIN955173) specifically detects Transferrin Receptor 2 in WB and EIA. The antibody is reactive with Human samples.

Quick Overview for Transferrin Receptor 2 antibody (C-Term) (ABIN955173)

Target: Transferrin Receptor 2 (TFR2)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Transferrin Receptor 2 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Product Details anti-Transferrin Receptor 2 Antibody

Binding Specificity: AA 673-703, C-Term

Specificity: This antibody detects Human TFR2 (C-term). Other species not tested.

Purification: Protein A column followed by peptide affinity purification

Immunogen: KLH conjugated synthetic peptide between 673-703 amino acids from the C-terminal region of human TFR2

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS, 0.09 % (W/V) Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to six months or (in aliquots) at -20 °C for longer.

Target Details for Transferrin Receptor 2

Target: Transferrin Receptor 2 (TFR2)

Alternative Name: TFR2

Background: This gene is a member of the transferrin receptor-like family and encodes a single-pass type II membrane protein with a protease associated (PA) domain, an M28 peptidase domain and a transferrin receptor-like dimerization domain. This protein mediates cellular uptake of transferrin-bound iron and mutations in this gene have been associated with hereditary hemochromatosis type III. Alternatively spliced variants which encode different protein isoforms have been described, however, not all variants have been fully characterized. Function: Mediates cellular uptake of transferrin-bound iron in a non-iron dependent manner. May be involved in iron metabolism, hepatocyte function and erythrocyte differentiation. Cellular Location: Cell membrane, Single-pass type II membrane protein. Tissue Location: Predominantly expressed in liver. While the alpha form is also expressed in spleen, lung, muscle, prostate and peripheral blood mononuclear cells, the beta form is expressed in all tissues tested, albeit weakly.Synonyms: Transferrin receptor protein 2

Molecular Weight: 88755 Da (Calculated)

Gene ID: 7036

NCBI Accession: NP_001193784

Pathways: Transition Metal Ion Homeostasis