THO Complex 4 antibody (Middle Region)

Catalog No. ABIN955189

This Rabbit Polyclonal antibody specifically detects THO Complex 4 in WB and EIA. It exhibits reactivity toward Human and has been mentioned in 2+ publications.

Quick Overview for THO Complex 4 antibody (Middle Region) (ABIN955189)

Target: THO Complex 4 (THOC4)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This THO Complex 4 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Product Details anti-THO Complex 4 Antibody

Binding Specificity: AA 59-89, Middle Region

Specificity: This antibody detects THOC4 / ALY (Center).

Cross-Reactivity (Details): Species reactivity (tested):Human

Purification: Protein A column followed by peptide affinity purification

Immunogen: KLH conjugated synthetic peptide between 59-89 amino acids from the Central region of human THOC4

Isotype: Ig Fraction

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store at 2 - 8 °C for up to six months or (in aliquots) at -20 °C for longer.

References for anti-THO Complex 4 antibody (ABIN955189)

Souki, Sandri-Goldin: "Arginine methylation of the ICP27 RGG box regulates the functional interactions of ICP27 with SRPK1 and Aly/REF during herpes simplex virus 1 infection." in: Journal of virology, Vol. 83, Issue 17, pp. 8970-5, (2009) (PubMed).

Johnson, Li, Sandri-Goldin: "The cellular RNA export receptor TAP/NXF1 is required for ICP27-mediated export of herpes simplex virus 1 RNA, but the TREX complex adaptor protein Aly/REF appears to be dispensable." in: Journal of virology, Vol. 83, Issue 13, pp. 6335-46, (2009) (PubMed).

Target Details for THO Complex 4

Target: THO Complex 4 (THOC4)

Alternative Name: THOC4 / ALY

Background: THOC4 is a heat stable, nuclear protein and functions as a molecular chaperone. It is thought to regulate dimerization, DNA binding, and transcriptional activity of basic region-leucine zipper (bZIP) proteins.Synonyms: Ally of AML-1 and LEF-1, BEF, THO complex subunit 4, THO4, Transcriptional coactivator Aly/REF, bZIP-enhancing factor BEF

Gene ID: 10189

NCBI Accession: NP_005773